Consistent with our mouse studies, we detected significantly higher MYB mRNA levels in one secondary AML and one RAEB-2 patient samples with SETBP1 missense mutations than in healthy bone marrow samples, which normally express significant levels of MYB due to its expression in normal myeloid progenitors and also in erythroid and lymphoid cells [26] (Supplementary Figure S8). This evidence concerns the gene SETBP1 and acute myeloid leukemia.