SETBP1 and leukemia: Given that less significant differences in the levels of Setbp1 proteins were detected in these cells (Supplementary Figure S1), these results suggest that Setbp1 missense mutants are more potent transcriptional activators than wild-type Setbp1 and their ability to activate higher levels of target gene transcription could be at least partly responsible for their increased capability to induce leukemia development.