We have previously identified Hoxa9, Hoxa10, and Runx1 as critical transcriptional targets of wild-type Setbp1. It is possible that faster leukemia development induced by Setbp1(I/T) and Setbp1(D/N) than wild-type Setbp1 could be due to their capability to induce more potent effects on the transcription of these target genes. The gene discussed is RUNX1; the disease is leukemia.