In contrast, 14 pathways of the top 30 enriched pathways were only linked with CLP including dopaminergic synapses, endocytosis, the GnRH signalling pathway, morphine addiction, non-small cell lung cancer, renin secretion, acute myeloid leukaemia, bile secretion, dorso-ventral axis formation, endometrial cancer, renal cell carcinoma, shigellosis, SNARE interactions in vesicular transport, and Sphingolipid metabolism. This evidence concerns the gene REN and hereditary clear cell renal cell carcinoma.