WIPF1 and neoplasm: We also found that WIPF1 expression was significantly associated with tumor extrathyroidal invasion (P=0.011, Figure 7B) and lymph node metastasis (P=2.64E-05, Figure 7C), suggesting that WIPF1 promotes poor clinicopathological outcomes of thyroid cancer, consistent with an important role of WIPF1 in the aggressiveness of this cancer.