Correspondingly, on tumor analysis, we confirmed that BRAF protein was dramatically decreased in the BRAF knockdown cells but not in the WIPF1 knockdown cells, while WIPF1 protein was dramatically decreased in cells either with BRAF knockdown or WIPF1 knockdown (Figures 5E and 5F), which was consistent with the above results of reduced WIPF1 expression after BRAF knockdown in the cells. The gene discussed is BRAF; the disease is neoplasm.