We also found that WIPF1 expression was significantly associated with tumor extrathyroidal invasion (P=0.011, Figure 7B) and lymph node metastasis (P=2.64E-05, Figure 7C), suggesting that WIPF1 promotes poor clinicopathological outcomes of thyroid cancer, consistent with an important role of WIPF1 in the aggressiveness of this cancer. This evidence concerns the gene WIPF1 and thyroid cancer.