In the past few years, many additional T2D risk loci have been identified including TCF7L2, FTO, HHEX, SLC30A8, HMG20A, IGF2BP2, MYSM1, TNFSF4, MYT1L, KIAA0825, VEGFA, PLXDC2, CREB5, NOS3, ARHGAP22, IGF1 [13–21]. The gene discussed is PLXDC2; the disease is type 2 diabetes mellitus.