Although our study suffered from some limitations, such as a relatively small sample size and a lack of data on the lifestyle habits of patients (e.g., active smoking, quality of sleep, weight loss, and diet), our results indicated that seven SNPs in MYSM1, PLXDC2, ARHGAP22, and HS6ST3, increase T2D risk in the Chinese Han population. This evidence concerns the gene PLXDC2 and type 2 diabetes mellitus.