Conversely, transplantation of wild-type BM into CCR5-/- mice was not sufficient to rescue the reduced tumor growth and vascularization seen in CCR5 null mice, indicating that recruitment of CCR5+ BM-derived cell populations does not significantly contribute to the pro-angiogenic effects of CCL5/CCR5 signaling in breast tumors. Here, CCL5 is linked to breast neoplasm.