Interestingly, the number of CCR5+ endothelial cells, as a proportion of total vasculature, was higher in malignant tumors than in DCIS lesions: TNBC, P = 0.0017; HER2+, P = 0.0138; ER+, P < 0.0001 (Figure 4E and Supplementary Table S6B, S6C). This evidence concerns the gene ESR1 and cancer.