Tao et al [32] also identified that the deletion allele of a 5-base pair indel polymorphism (rs145204276) in the promoter region of GAS5 significantly increased the risk of hepatocellular carcinoma (HCC) and increased the expression of GAS5 in hepatocellular cell lines, which indicated the differential roles of GAS5 in carcinogenesis of different cancer types. This evidence concerns the gene GAS5 and cancer.