In view of the fact that mTORC1 hyperactivity sensitises tumour cells to mild genotoxic stress, and ‘incomplete’ mTORC1 inhibition by Rapa may inadvertently rescue this phenotype employing mild genotoxic stress as an approach may aid in selective elimination of TSC-lacking tumour cells, also overcoming Rapa-refractory tumours. This evidence concerns the gene TRERF1 and neoplasm.