It was less evident, however, that SCLC cells with RICTOR CN gain demonstrated parallel increases in basal mTORC2 complex (RICTOR) signaling, measured by increased phosphorylation of its downstream targets SGK, PKCα, and AKT, compared to cell lines with no gain in RICTOR CN (Figure 2B). The gene discussed is RICTOR; the disease is small cell lung carcinoma.