CHEK1 and pancreatic adenocarcinoma: In particular, analysis of UCSC Cancer Genomics database (https://genome-cancer.ucsc.edu/) suggests that colon/rectum and pancreatic adenocarcinoma show upregulation of multiple kinases (AURKA/B, CHEK1, MET, etc) (Figure 9), which are potently inhibited by BPR1K871.