DNMT1 and acute myeloid leukemia: While BMI1 depletion is associated with the re-expression of CDKN2A (p16) [39, 53], DNMT1 depletion might partially explain the increased expression of CDKN2B (p15): Previous reports showed a correlation between CDKN2B (p15) methylation and higher DNMT1 expression as well as an association of DNMT1 downregulation and p15 re-expression in AML [33, 42].