It is an anti-hyperlipidemic agent that can reduce redox imbalances by reducing myocardial lipid peroxidation and increasing the antioxidant system [23, 24] and by downregulating a number of key pro-inflammatory mediators such as NF-κB, TGF-β, HSP70 and TNF-α in a diabetes rabbit model produced by alloxan [9].Therefore, it is likely that probucol exerts multiple effects on Na+ channel during pathophysiological conditions through reduction in NF-κB- and PKC-mediated oxidative stress. This evidence concerns the gene TNF and diabetes mellitus.