APAF1 and diffuse large B-cell lymphoma: The critical importance of this mislocalization of Apaf-1 in the overall biology of DLBCL is further supported by our results demonstrating the ability of small molecules that disrupt raft-like domains via their effect on cholesterol (MCD) or lipid peroxidation via ROS production (Ly30 and C1); however, the precise mechanism underlying the lipid raft recruitment of Apaf-1 is still the focus of our ongoing investigations.