Corroborating the association between an absence or downregulation of Apaf-1 expression and drug resistance and/or aggressiveness of cancer, we previously reported a hitherto undefined mechanism of defective apoptosome signaling in human B cell lymphoma cell lines by demonstrating the sequestration of Apaf-1 to the plasma membrane [14]. Here, APAF1 is linked to B-cell non-Hodgkin lymphoma.