Thus, these findings indicate that the PI3K/Akt-mTOR- eIF4G2 signaling pathway is a sensitive sensor of metabolic stresses in both the extracellular and intracellular environments and Lewis y antigen participates in regulating autophagy-autophagic cell death in ovarian cancer cells likely via this signaling pathway. The gene discussed is EIF4G2; the disease is ovarian cancer.