CTRL and ovarian carcinoma: However, the data do demonstrate that at the early stages of autophagy, the activity of the peptidyl glutamyl-peptide hydrolase-like and chymotrypsin-like proteasomes were increased in ovarian cancer cells of high-grade malignancy, but when excessive autophagy of cells was induced by external and internal harsh environments autophagic death occurred in a large number of cells and the activities of trypsin-like and peptidyl glutamyl-peptide hydrolase-like proteasomes were decreased.