BSG and neoplasm: Several investigators have shown that glycosylation degree determines the activity of the ability of the CD147 molecule to stimulate fibroblasts and tumor cells to secrete MMPs; highly glycosylated transmembrane CD147 interacts with the monocarboxylate transporter (MCT), cyclosporin A, and integrin to promote cellular adhesion, mediate lactic acid transport, and induce signal conversion in cells [18, 33].