Mechanistically, we first demonstrated that hnRNPK maintained anti‐apoptosis and promoted chemoresistance in bladder cancer cells via transcriptional regulation of XAF1 and ERCC4. A recent study revealed that XAF1 is down‐regulated in bladder cancer and associated with good prognosis 40, 41. The gene discussed is XAF1; the disease is urinary bladder cancer.