Epigenetic deregulation has been shown to play an important role in neuroblastoma pathogenesis, silencing neuroblastoma suppressor genes by aberrant promoter DNA hypermethylation, for example, RASSF1A, CASP8, and DCR219, 20, 21, 22, or by aberrant histone methylation, for example, CASZ1, CLU, RUNX3, NGFR 23, and p14ARF24. The gene discussed is CLU; the disease is neuroblastoma.