MEGF10 and neuroblastoma: It therefore possible that many neuroblastoma cell lines derive from a subpopulation of cells within high‐risk tumors that is hypermethylated at MEGF10. Alternatively, DNA hypermethylation of MEGF10 in neuroblastoma cell lines may represent a long‐term stable epigenetic mark that serves to “lock” the silenced state in a gene that is normally repressed in neuroblastoma tumors by histone modifications 60.