Both of those MEGF10‐hypermethylated tumors were high‐risk 32 and in our data all the hypermethylated tumors were stages 3 or 4, and showed decreased overall survival (Figure 3F), suggesting that MEGF10 DNA hypermethylation occurs predominantly in an aggressive subset of neuroblastomas. The gene discussed is MEGF10; the disease is neuroblastoma.