It therefore seems likely that MEGF10 expression is silenced in most neuroblastomas by epigenetic mechanisms other than DNA methylation, such as repressive histone modifications H3K27me3 and/or H3K9me2, as we have shown in the SHIN cell line (Figure 4), and as has been reported for other neuroblastoma tumor suppressor genes 23, 24, 55. Here, MEGF10 is linked to neoplasm.