Therefore, the aims of this cohort study were to investigate (1) the lipid profiles at subclass levels in CKD patients, (2) the relationships between lipid profiles and CKD progression, and (3) the relationships between lipid profiles, ankle-brachial index (ABI) as a marker of atherosclerosis in the peripheral artery, and (4) levels of the CKD-MBD-related markers (Klotho and FGF23) using HPGPC. The gene discussed is KL; the disease is atherosclerosis.