We previously generated a mouse model of angiotensin II-induced hypertension (the Tsukuba hypertensive mouse; THM) that overexpresses both a 15-kb hREN Tg bearing 2.8-kb of 5'-flanking sequence and a 14-kb hAGT Tg (Fig 1A, [24]). The gene discussed is AGT; the disease is Hypertension.