Endo G released from the mitochondria interacts with AIF in the nucleus and is involved in caspase-independent apoptosis in Caenorhabditis elegans [43, 44]; in neurodegenerative disease, both Endo G and AIF expression levels are decreased in the mitochondria but are increased in the nuclei [45]. The gene discussed is AIFM1; the disease is neurodegenerative disease.