These cases were further tested by FISH and three of them (75%) exhibited co-amplification of PD-L1/JAK2/PD-L2 genes (Fig 2C and 2D); two cases exhibited low amplification (~4 copies of PD-L1 gene) while the third case harbored ≥6 copies of PD-L1 per tumor cell. The gene discussed is CD274; the disease is neoplasm.