TLR4 and nutritional deficiency disease: In multivariate analysis, malnutrition (SGNA score>1), high plasma sCD14 level (>3.7 μg/mL), high endotoxin level (>2.3 EU/mL), single or double TLR4 +896A/G or CD14 -159C/T variant alleles carriers were associated with increased severe sepsis risk in febrile de-compensated cirrhotic patients (Table 3).