Notably, current study revealed that variant alleles of TLR4+896A/G and CD14-159C/T modulate immunologic protein abundance (increase plasma sCD14 levels/up-regulated TLR4 expression on non-classical inflammatory monocyte and down-regulated HLA-DR and mCD14 expression on classical monocyte) and function (impaired phagocytosis of classical monocytes) in our febrile acute de-compensated cirrhotic patients with severe sepsis. The gene discussed is CD14; the disease is Sepsis.