Corresponding to the enhanced LPS-stimulated TNFα/nitrite production, the significantly up-regulated NFκBp65, p-iNOS and p38MAPα mRNA and protein expressions were found on cultured monocyte of TLR4+896A/G variant allele carriers and severe sepsis cases (Fig 1F–1H, Fig 2A–2C). Here, TLR4 is linked to Sepsis.