However, the percentage of carrying variant alleles of the following SNPs including TLR4 3′UTR, G/C; CD14 ′UTR, C/A; TNFα -238G/A; IL-1β -31T/C; IL-1β +3954C/T; IL-6 -174G/C; IL-6 -597G/A were not different among healthy controls, severe sepsis febrile de-compensated cirrhotic patients, non-severe sepsis febrile de-compensated cirrhotic patients and afebrile compensated cirrhotic patients (Table 1 and S3 Table). The gene discussed is TLR4; the disease is Sepsis.