Our study revealed that LPS-stimulated IL-1β/IL-6 production in cultured supernatant of non-classical monocyte and plasma IL-1β/IL-6 levels were not significantly different between our TLR4+896A/G or CD14-159C/T variant and wild-type allele carriers as well as between severe sepsis and non-severe sepsis cases. The gene discussed is TLR4; the disease is Sepsis.