In our study, the lack of association between the TNFα-308G/A, TNFα-238G/A, IL-6-174G/C, IL-6-597G/A, IL-1β-31T/C and +3954C/T polymorphisms and severe sepsis risk suggested that these inflammatory cytokines might influence sepsis progression via mechanisms other than regulations by these polymorphisms. Here, IL1B is linked to Sepsis.