Schürmann B et al. showed that clusterin SNP risk allele rs11136000 was significantly related to lower plasma clusterin values in an allele-dose dependent manner with genotype distribution of major allele frequency in AD (0.66) and controls(0.63).[12] Xing YY et al also identified that rs9331888 allele was related to a decreased plasma clusterin values.[13] Both Schurman et al and Xing et al have shown that particular SNP risk alleles(in allele dose dependent manner) are associated with lower plasma clusterin. This evidence concerns the gene CLU and Alzheimer disease.