In support of this, MMP1 levels were previously reported to be elevated in patients with mild fibrosis compared to healthy controls, but diminished in cirrhosis[26], and we recently demonstrated exacerbated fibrosis in mice deficient in macrophage Wnt production which was associated with reduced Mmp13 expression (the murine ortholog of MMP1)[28]. The gene discussed is MMP13; the disease is Cirrhosis.