The optimum multivariable prediction model from the 33 analytes remaining after controlling for missing data and 4 clinical co-variates (age, BMI, APRI and diabetes), incorporated MMP7, MMP1, AFP, PDGF-AA, APRI and age (Table 2, AUROC = 0.928, “ELISA model”). Here, MMP1 is linked to diabetes mellitus.