Previously, we made a whole-genome analysis for copy number variations (CNV) in community-dwelling Japanese elderly and found that a segmental copy number loss in the 12-kb region within intron 2 of the SFMBT1 (Scm-like with four MBT domains protein 1) gene was observed in 4 of 8 subjects (50%) with possible iNPH and AVIM (asymptomatic ventriculomegaly with features of iNPH on MRI) [9]; AVIM seems to be a pre-symptomatic state of iNPH [10,11]. Here, SFMBT1 is linked to Ventriculomegaly.