Based on this result, we assessed potential differences in macrophage infiltration or activating microglia cells in ischemic brain between genotypes, given that they can induce acute inflammation in brain ischemia.[27] To do so, we compared the number of MAC-3-positive cells in the cerebral hemisphere of WT and Angptl2 KO mice. The gene discussed is ANGPTL2; the disease is brain ischemia.