Our in vitro experiments using RAW264.7 macrophages indicated that rANGPTL2 treatment promotes a gradual increase in expression of the anti-inflammatory cytokine IL-10 after a more rapid increase in levels of inflammatory cytokines, although IL-10 transcript levels were not altered by ANGPTL2 KO in the acute phase of ischemic stroke. The gene discussed is IL10; the disease is ischemic stroke.