ANGPTL2 and metabolic syndrome: Several previous reports indicate that ANGPTL2 is a potent activator of macrophages and enables them to acquire pro-inflammatory phenotypes in various non-infectious, chronic inflammatory diseases, such as metabolic syndrome and atherosclerotic vascular disease.[14, 16, 17] However, little evidence has been reported relevant to the role of ANGPTL2 in acute ischemic disease.