VPS35 and Mental deterioration: Nevertheless, beside the typical PPD phenotype, we documented many more signs reported in the FBXO7 in our patient—supranuclear gaze palsy, blepharospasm, eyelid apraxia, dysarthria, dysphagia, hypophonia, respiratory signs, and cognitive decline.[20,23,24] From this point of view, this patient's disease would be more probably associated with the presence of the FBXO7 mutation of than with the VPS35 mutation.