MAZ, as a member of zinc finger protein, not only plays an important role in the regulation of blood-brain barrier and colitis caused by hypoxia [30, 31], but also regulates gene expression of p53, c-Myc, VEGF, Ras, PDPN and caveolin-1 [13–16, 27, 30]. The gene discussed is PDPN; the disease is colitis.