Even with the advent of very effective novel single agent signal inhibitor therapy, CIT remains the standard of care for patients with previously untreated CLL particularly those with mutated IGVH status.[1, 46] The addition of anti-VEGF therapy to CIT did produce higher complete response rates and resulted in longer progression-free and treatment-free survival, when compared to chemoimmunotherapy alone, independently from IGHV mutational status. The gene discussed is VEGFA; the disease is B-cell chronic lymphocytic leukemia.