[36] Indeed CLL cells secrete these 2 chemokines in response to BCR stimulation, to attract accessory cells and enhance their microenvironment and this activity can be a candidate for a distinct disease progression event.[37, 38] Other studies have convincingly demonstrated that baseline CCL-3 levels associate with survival in CLL and other B-cell malignancy, in concordance with our results.[39, 40]. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.