[15–17] Higher VEGF levels have also been shown to predict less favorable outcomes among CLL patients receiving CIT, providing further rationale for testing the effect of anti-VEGF therapy in combination with CIT for patients with CLL.[18] Here we conducted a randomized phase 2 CIT trial where we used pentostatin, cyclophosphamide, and rituximab with (PCR) with an anti-VEGF agent, bevacizumab (PCR-B), or without bevacizumab (PCR) for patients with progressive but previously untreated CLL. Here, VEGFA is linked to B-cell chronic lymphocytic leukemia.