To confirm whether Nec‐1 administration could also affect AD‐like cognitive impairment of a different mouse model, we acutely induced memory deficits in Imprinting Control Region (ICR) mice (8‐week‐old male, n = 8 per group) by intracerebroventricular injection of Aβ(1–42) aggregates (Fig 2F and G). This evidence concerns the gene PCSK1 and Alzheimer disease.