With no overt symptoms of cognitive impairments until substantial levels of Aβ aggregation and tau hyperphosphorylation are accumulated in pre‐symptomatic stage, however, AD is mostly diagnosed in later stages when irreversible degree of neural cell death and brain atrophy make full recovery from AD impractical (Jack et al, 2010, 2013). The gene discussed is MAPT; the disease is Alzheimer disease.