Polymorphisms in genes implicated in inflammation predispose to AMD (Hageman et al, 2005) with strong linkage to single nucleotide polymorphisms in CFH factors, CFHR (CFH‐related factors), ARMS2, VEGFA, and TGFBR1 (Ambati et al, 2003a; Klein et al, 2005; Yu et al, 2011; Ratnapriya & Chew, 2013), yet by themselves, no single mutation can account for disease development. Here, ARMS2 is linked to age-related macular degeneration.