Synovial expression of ALX mRNA in the MIA‐induced model of OA pain was positively correlated with key inflammatory genes (TNF, IL‐1β, IL‐6, and COX‐2), which is consistent with the presence of synovial inflammation in this model of OA pain, described herein and in previous studies 31, 32, 33, and the expression of ALX by neutrophils, macrophages, and fibroblast‐like synoviocytes 34. This evidence concerns the gene TNF and inflammatory response.