Recently, several novel delivery strategies have been developed to reduce off‐target effects, especially nanoparticles that are characteristic by improved stability, extremely small size, biocompatibility and self‐assembly.145, 146 Administration of HOTAIR siRNA by using magnetic nanoparticles has been shown to effectively inhibit the proliferation, invasion and in vivo tumourigenicity of human glioma stem cells.147 The use of nanoparticles as effective delivery vehicles for lncRNAs is thus highly attractive and deserves further studies. The gene discussed is HOTAIR; the disease is central nervous system cancer.