It has been reported that bromodomain‐containing 4 (BRD4), a small molecule inhibitor, can downregulate HOTAIR expression and then inhibit glioblastoma tumour growth.138 Another small molecule inhibitor that blocks the binding of HOTAIR to its partners is also found to protect against tumour cell proliferation, invasion and metastasis.139 Given the fact that HOTAIR plays an important role in promoting OA progression,84 in vivo delivery of small molecule inhibitors for HOTAIR may have a potential therapeutic benefit for OA patients. This evidence concerns the gene HOTAIR and glioblastoma.