However, in subgroup with PSA ranged from 4 to 10 ng.ml−1, the accuracy level increased by 4.6% in prediction of PCa (AUC 0.830, AUC 0.784, respectively) (Fig. 2B), but decreased in prediction of advanced PCa (AUC 0.806, AUC 0.861, respectively) (Fig. 3B), when added the NLR value into the multivariate logistic model. This evidence concerns the gene KLK3 and posterior cortical atrophy.