The AUC-ROC of serum KIM-1 for identifying renal dysfunction from all these populations, including both ADV and ETV treatment groups, was 0.94 (95% CI, 0.87 to 1.02; P < 0.001), while the AUC-ROC of serum creatinine was only 0.82 (95% CI, 0.60 to 1.03; P < 0.01) (Fig. 3). This evidence concerns the gene HAVCR1 and Abnormal renal physiology.