Targeting of each of the IgG-IL2v molecules (CEA-IL2v, FAP-IL2v, and DP47-IL2v) to the various compartments of the 3D heterotypic spheroids was assessed using 100 nM of fluorescently labeled molecules (Fig. 2) CEA-IL2v penetrated the spheroid and remained targeted to the tumor cell compartment. This evidence concerns the gene IGHV3-23 and neoplasm.