Subgroup analysis by baseline hyperinsulinemia (Figure 3) showed that hyperinsulinemic subjects (baseline insulin AUC0−120, 13,374 ± 498 mU · min · L−1) experienced significantly greater reductions in insulin AUC0−120, arterial norepinephrine concentration, whole-body norepinephrine spillover rate, and heart rate than normoinsulinemic counterparts (baseline insulin AUC0−120, 6598 ± 352 mU · min · L−1), despite similar weight loss (−7.7 ± 0.6 and −7.6 ± 0.6 kg, respectively). The gene discussed is INS; the disease is hyperinsulinism.