CACNA1A and Anxiety: The ratio of time spent in the center gradually increased in both groups (significant effect of time F(2.9) = 6.328, P = 0.002; no significant effect of group × trial interaction F(2.9) = 0.341; P = 0.789; repeated measure ANOVA), which indicates that the selective deletion of Cav2.1 did not affect anxiety-like behavior.