HTT and Huntington disease: Given that MGO increased HTT aggregation and toxicity in cell models, we next investigated whether glycation also affected neuronal loss in vivo, employing a Drosophila model of HD based upon the pan-neuronal expression of a HTT exon 1 fragment with 93 or 20 glutamines (HTT93Q or HTT20Q) via the GAL4/UAS system35.