Histologic signs of kidney destruction, AKI to CKD transition and renal fibrosis, as estimated by morphology based on Masson trichrome staining (Supplemental Figure 1a,b) or by immunoblot analysis of kidney specimens for collagen I and fibronectin (Supplemental Figure 1c~e), were all improved by early Tanshinone IIA treatment to a significantly greater extent when compared with late Tanshinone IIA treatment for the same period. Here, FN1 is linked to chronic kidney disease.