GSK3B and acute kidney injury: Conversely, sodium nitroprusside, a GSK3b activator48, offset the effect of Tanshinone IIA on the GSK3β/MAPK kinases signaling pathways and abolished its renoprotective activity, suggesting that the fundamental mechanism responsible for the beneficial effect of Tanshinone IIA in AKI may lies in its regulation of the signaling activity of GSK3β/MAPK kinases pathway.