In fact, Van Raemdonck et al. showed that platelet-derived CXC chemokines, CXCL4 and CXCL4L1, inhibited lymphatic endothelial cell proliferation in vitro, reduced proliferation of MDA-MB-231 cells in vitro and decreased MDA-MB-231 tumor growth in vivo43. This evidence concerns the gene PF4V1 and neoplasm.