Whereas, our findings confirm a significant association in Lebanese BC patients between the expression levels of FOSL1, Acyl-CoA synthetase bubblegum family member 1 (ACSBG1), and Chromosome 21 open reading frame 37 (C21orf37) genes with ER/PR expression and family history of ovarian cancer. The gene discussed is ESR1; the disease is ovarian carcinoma.