CRPPA and malaria: More recently, a chemical rescue screen identified 4 (1R,3S-MMV008138) from the Medicines for Malaria Venture (MMV) “malaria box” as a potent inhibitor of P. falciparum IspD (PfIspD), showing nanomolar inhibition of recombinant enzyme activity and sub-micromolar inhibition of parasite growth (Fig. 2)19, 20, 21, 22.