HoipΔFoxp3 mice exhibited severe immune pathology, including lymphadenopathy, lymphocytic perivascular infiltration and tissue destruction of the lung, liver and exocrine pancreas, hyper-IgE production and abnormally high numbers of activated CD4+ and CD8+ T cells (CD44highCD62LlowKI-67+; Fig. 7d–h and Supplementary Fig. 5a–c). The gene discussed is IGHE; the disease is Lymphadenopathy.