CTH and kidney disorder: Although most of the literature supports the notion that hydrogen sulfide protects against oxidative stress and thus generally also against renal disease (Koning et al, 2015; Lobb et al, 2015), some recent studies suggest that treatment with the CSE inhibitor propargylglycine (PAG) inhibits endogenous H2S production and increases antioxidant enzyme expression while significantly improving renal function reducing renal damage, fibrosis, and inflammation.