CTCF and leukemia: On comparison of our Capture-C data with CTCF ChIP-seq data (an ENCODE data set from K562 cells, ENCSR000DMA) that demarcates compartment boundaries, the major interaction site appears to be clustered at the 3′ end of BCL-2 (Fig. 4C, D), thus marking a putative 3′ enhancer in MLL-AF4 leukemia cells.