TRDN and myopathy: Given that triadin null mice presented with what appears to be a “normal” phenotype, it was suggested by Shen et al. (2007) that the role triadin plays in muscle function is minor or replaced with a compensatory mechanism [131] Conversely, according to Oddoux et al. (2009), a decrease in muscle strength in triadin null mice, suggests triadin dysfunction may lead to the development of a myopathy and is therefore essential for skeletal muscle function.