CD8A and nonpapillary renal cell carcinoma: We performed clonality assessment on the TCGA ccRCC cohort using SciClone [60] (see “Clonality assessment” in “Methods”); and consistent with the NSCLC study, found that more clonal tumors (i.e. tumors with fewer subclones) had higher levels of CD8+ T cells, cytotoxic cells, APM, and TIS (Fig. 7c).