PBRM1 and nonpapillary renal cell carcinoma: Out of the 11 driver genes commonly mutated in ccRCC, only PBRM1 was mutated at significantly different rates between the three populations (Additional file 1: Figure S21a; higher in non-enriched versus T cell enriched q = 0.04; higher in heterogeneous versus T cell enriched q = 0.04; Fisher’s exact).