Coupled with the observation that inhibitory checkpoint molecules PD-1 and CTLA-4 are also expressed at high levels in the T cell enriched class, this finding suggests that effector T cells in the tumor microenvironment may not be able to exert their pro-survival effects due to being offset by inhibitory cells/molecules and factors such as exhaustion and/or anergy. The gene discussed is CTLA4; the disease is neoplasm.