CD274 and leukemia: Interestingly, the in silico analysis of data extracted from the curated databases (the HemaExplorer, http://servers.binf.ku.dk/hemaexplorer/) or Leukemia Gene Atlas (LGA) (http://www.leukemia-gene-atlas.org/LGAtlas/) showed that the level of expression of CD274 in AML cells was much higher than that in normal hematopoietic stem cells, which was inversely correlated to the overall survival of AML patients (Additional file 3: Figure S2A-B) [27].