Although the use of antioxidants and supplementation of enzyme cofactors can be conceivably envisaged, the prominent renoprotective effect of angiotensin II type 1 receptor blocker (ARB) Telmisartan in type 2 diabetes, a condition associated with microalbuminuria as SCA has been reported to be mediated through enhancing antioxidant defense capacity and reducing oxidative stress [6]. The gene discussed is AGTR1; the disease is autosomal dominant cerebellar ataxia.