TGFB1 and autosomal dominant cerebellar ataxia: Oxidative stress has been reported to oxidize angiotensinogen and convert it to angiotensin II (ATII) and to increase secondary angiotensin type 1 receptor (AT1R)-mediated generation of transforming growth factor-beta (TGFβ) in the kidney in SCA; excessive AT1R signaling causes SCA glomerulopathy [15, 16].