For example in early diabetes treatment increased levels of Ugt1a2 (+5.41 FC), S100a9 (+4.23 FC), Plk3 (+3.82 FC), and Lcn2 (+3.38 FC) and decreased levels of Cyp24a1 (-2.51 FC) and Tfpi2 (-1.76 FC), genes whose expression changes were not evident with late treatment using our cut off criteria. This evidence concerns the gene PLK3 and diabetes mellitus.