Lastly, given the limited neurodegeneration observed in the CNS of IFNAR KO mice at peak of disease and the rapidity of death in the IFNAR KO mice, it is possible that infection of the peripheral organs contribute to the lethality of ZIKV infection in IFNAR KO mice, and thus although the mice show clear signs of neurological damage, additional studies will be needed to establish the cause of death in the infected IFNAR KO mice. Here, IFNAR1 is linked to infection.