IFNAR1 and Zika virus infectious disease: In this study we establish a new model of subcutaneous (SC) ZIKV infection in neonatal (1 day old), immunocompetent C57BL/6 (B6 WT) mice and compare its clinical progression, virus distribution, immune response, and neuropathology with C57BL/6-IFNAR-/- (IFNAR KO) mice, which are deficient in type 1 IFN responses.