ADAMTS5 and infection: We intranasally infected Adamts5-/- mice and C57.BL/6 controls with 104 pfu/mouse-adapted X31 (H3N2) influenza virus, and observed enhanced weight loss (p < 0.05 on day 8 p.i.)in Adamts5-/- mice across the experimental infection period when compared to C57.BL/6 controls (Fig 2A).