Increased influenza-specific DbNP366-372 and DbPA224-233 CD8+ T cell numbers were also detected by tetramer staining in the spleen of Adamts5-/-Vcan+/hdf versican reduced) mice at day 10 p.i. when compared to Adamts5-/-Vcan+/+ controls (Fig 8B). This evidence concerns the gene ADAMTS5 and influenza.