VCAN and influenza: Results from our transwell migration assays and Adamts5-/-Vcan+/hdf mouse studies further support our hypothesis that the absence of ADAMTS5 reduces ECM proteoglycan cleavage and impedes (but does not entirely block) the movement of influenza-specific lymphocytes to effector sites, such as the lung or to the periphery (Figs 7 and 8).